Scientific Challenge: The metabolic changes driving epithelial-to-mesenchymal transition (EMT) in pancreatic cancer remain incompletely characterized.
Study Type: Metabolomics
Our Contribution: Nelson Scientific Labs supported high-resolution LC-MS metabolomics to profile metabolic shifts during TGFβ-induced EMT in pancreatic cancer cells, with validation in patient samples.
Key Findings: EMT was associated with disrupted amino acid and energy metabolism and unexpected elevation of retinoic acid, which contributed to extracellular matrix remodeling linked to invasion.
Research Impact: These findings identify metabolic pathways that regulate EMT and highlight potential therapeutic targets for early intervention in pancreatic cancer progression.
Publication: https://doi.org/10.3390/cancers13246204