Scientific Challenge: Long-duration space missions expose astronauts to chronic low-dose cosmic radiation, yet reliable biomarkers of radiation-induced health effects remain limited.
Study Type: Lipidomics | Metabolomics | Space Radiation
Our Contribution: Nelson Scientific Labs performed plasma metabolomic and lipidomic profiling in murine models exposed to space-relevant oxygen ions and protons, comparing molecular responses with conventional gamma radiation.
Key Findings: Low-dose space-type radiation disrupted glycerophospholipid, amino acid, and fatty acid metabolism while inducing dyslipidemia and lipid peroxidation consistent with systemic inflammatory responses.
Research Impact: These findings identify candidate plasma biomarkers for space radiation exposure and contribute to strategies for monitoring astronaut health during deep-space missions.
Publication: https://doi.org/10.3390/metabo10060252